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In the actual era of nanomedicine, the current proposal consists in the development of a smart magnetic DNA bar coded nanohydrogel carrier for targeted delivery of anticancer therapy that would break through the barriers of the current knowledge with respect to precise quantification of the drug amount that reaches the targeted cells and produces the therapeutic effect. Nanohydrogels gained a lot of attention in the last years as they display the combined properties of both hydrogels and nanoparticles and have an open network filled with water, where various anticancer drugs and oligonucleotides could be incorporated. DNA offers unlimited barcoding possibilities, with extremely sensitive detection modalities such as sequencing, PCR and gel electrophoresis. Furthermore, the fluorescent labeling of the bar codes enables the imagistic and flow cytometry detection of the potential carrier’s uptake by the targeted tumor cells. Moreover, due to its magnetic properties, the system could be further in vivo magnetically guided to deliver the anticancer therapy in specific sites. Consequently, by using these magnetic nanohydrogels, loaded with various anticancer drugs and their corresponding synthetic DNA barcodes, we aim to find a correlation between the colon cancer cell viability and the amount of drug that reached the cells, according to the quantification of the barcodes.